Hsp90 inhibitors, methods of making and uses therefor

Inhibiteurs hsp90, procedes de realisation et d'utilisation correspondants

Abstract

The invention provides purified 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycin derivatives, pharmaceutically acceptable salts thereof and prodrugs thereof that are potent Hsp90 binding agents that are useful for the treatment and/or the amelioration of symptoms of cancer and other proliferative tissue disorders.
Cette invention concerne des dérivés purifiés de 18,21-didehydro-18,21-dideoxo-18,21-dihydroxy-geldanamycine, des sels pharmaceutiquement acceptables de ceux-ci ainsi que des promédicaments lesquels sont des agents de liaison à Hsp90 puissants particulièrement utiles pour le traitement et/ou l'amélioration de symptômes liés au cancer et d'autres affections tissulaires proliférantes.

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    See also references of EP 1863769A4

Cited By (16)

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    EP-1906950-A2April 09, 2008Infinity Discovery, Inc.Formulations d'ansamycine et leurs procedes d'utilisation
    EP-1906950-A4September 24, 2008Infinity Discovery IncAnsamycin formulations and methods of use thereof
    JP-2010509306-AMarch 25, 2010バイオチカ テクノロジー リミテッド新規化合物及びそれらの製造方法
    US-7566706-B2July 28, 2009Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7579337-B2August 25, 2009Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7608613-B2October 27, 2009Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7691840-B2April 06, 2010Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7767662-B2August 03, 2010Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7767663-B2August 03, 2010Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-7833997-B2November 16, 2010Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-8252779-B2August 28, 2012Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-8492370-B2July 23, 2013Bristol-Myers Squibb CompanyCompounds and methods for their production
    US-8551964-B2October 08, 2013The Regents Of The University Of ColoradoHsp90 inhibitors with modified toxicity
    US-8703755-B2April 22, 2014Infinity Pharmaceuticals, Inc.Analogs of benzoquinone-containing ansamycins and methods of use thereof
    US-8778921-B2July 15, 2014Infinity Pharmaceuticals, Inc.Ansamycin hydroquinone compositions
    US-9603829-B2March 28, 2017The Regents Of The University Of Colorado, A Body CorporateHSP90 inhibitors with modified toxicity