Isolation, expression genique et resistance chimiotherapeutique de cellules cancereuses motiles

Isolation, gene expression, and chemotherapeutic resistance of motile cancer cells

Abstract

Methods of isolating motile cells of interest from an animal tissue is provided. Also provided are methods of determining mRNA or protein expression of a gene in motile cells of interest from an animal tissue. Additionally, methods of determining whether a cancer in a tissue of a mammal is likely to metastasize are provided. Methods are also provided for inhibiting metastasis of a cancer in a tissue of a mammal. Further provided are methods of determining resistance of a motile cancer cell population in an animal tissue to a chemotherapeutic agent.
L'invention concerne des méthodes permettant d'isoler des cellules motiles d'intérêt provenant d'un tissu animal. L'invention concerne également des méthodes permettant de déterminer un ARNm ou l'expression protéique d'un gène dans des cellules motiles d'intérêt provenant d'un tissu animal. Ces méthodes permettent, en outre, de déterminer si un cancer dans un tissu de mammifère est susceptible de produire des métastases. L'invention concerne enfin des méthodes permettant d'inhiber les métastases cancéreuses dans un tissu de mammifère ainsi que des méthodes permettant de déterminer la résistance d'une population de cellules cancéreuses motiles dans un tissu animal à un agent chimiothérapeutique.

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    See also references of EP 1784646A2

Cited By (7)

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    EP-2126566-A2December 02, 2009Albert Einstein School of Medicine of Yeshiva University, Massachusetts Institute of Technology, Ifo-regina Elena Cancer InstituteMetastasenspezifische splice-varianten von mena und anwendungen davon bei der diagnose, prognose und behandlung von tumoren
    EP-2126566-A4June 02, 2010Einstein Coll Med, Massachusetts Inst Technology, Ifo Regina Elena Cancer InstMetastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
    US-7851144-B2December 14, 2010The University Of Washington, The University Of North Carolina At Chapel Hill, The University Of Pittsburgh, The Cleveland Clinic FoundationCompositions and methods for detecting cancer
    US-8409509-B2April 02, 2013Regents Of The University Of MinnesotaSystems and methods for analyzing a particulate
    US-8603738-B2December 10, 2013Albert Einstein College Of Medicine Of Yeshiva University, Massachusetts Institute Of Technology, Ifo-Regina Elena Cancer InstituteMetastasis specific splice variants of mena and uses thereof in diagnosis, prognosis and treatment of tumors
    US-9315867-B2April 19, 2016University Of Washington, University Of North Carolina At Chapel Hill, The Cleveland Clinic Foundation, University Of PittsburgCompositions and methods for detecting cancer
    US-9719142-B2August 01, 2017Albert Einstein College Of Medicine, Inc., Massachusetts Institute Of Technology, Ifo-Regina Elena Cancer InstituteMetastasis specific splice variants of Mena and uses thereof in diagnosis, prognosis and treatment of tumors