Unique compositions of zwitterionic phospholipids and bisphosphonates and use of the compositions as bisphosphate delivery systems with reduced gi toxicity

Compositions uniques de phospholipides zwitterioniques et de bisphosphonates et leur utilisation sous forme de systemes d'administration de bisphosphates presentant une toxicite gastro-intestinale limitee


Compositions and methods for treating osteoporosis using the compositions are disclosed where the compositions have reduced GI toxicity and improved bio-availability and include a bisphosphonate and zwitterionic phospholipid.
Compositions et procédés servant à traiter l'ostéoporose. Ces compositions présentent une toxicité gastro-intestinale limitée, ainsi qu'une biodisponibilité améliorée et contiennent un bisphosphonate et un phospholipide zwitterionique.




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Patent Citations (1)

    Publication numberPublication dateAssigneeTitle
    WO-0061111-A1October 19, 2000Astrazeneca AbFormulation pharmaceutique comprenant un bisphosphonate et un agent d'addition favorisant l'absorption du bisphosphonate

NO-Patent Citations (1)

    N. VAN ROOIJEN, A. SANDERS: "Manipulation of Kupffer cells by liposome encapsulated clodronate and propamidine-synergistic and antagonistic effects of liposomal phospholipids and drugs", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 162, no. 1-2, 1998, pages 51 - 58, XP001064839

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